Search results for "MHC Class I Gene"

showing 3 items of 3 documents

Oxidative stress induces the expression of the major histocompatibility complex in murine tumor cells.

2001

The effect of t-butyl hydroperoxide (t-BOOH) on the induction of the Major Histocompatibility Complex (MHC) class I genes has been studied in two cell clones (B9 and G2) of the methylcholanthrene-induced murine fibrosarcoma GR9. These two clones were selected based on their different biological and biochemical behavior specially related to their tumor induction capability when injected into a BALB/c mouse. t-BOOH (0.125 mM) induced the expression of H-2 molecules in both cell clones. In B9 cell clone, in which MHC basal expression is very low or absent, t-BOOH significantly induced H-2Kd, H-2Dd and H-2Ld molecules. In G2 cell clone the expression of MHC class I genes was also enhanced by th…

FibrosarcomaCellElectrophoretic Mobility Shift AssayBiologyMajor histocompatibility complexBiochemistryMajor Histocompatibility ComplexTransactivationMiceAntigentert-ButylhydroperoxideCell CloneMalondialdehydeMHC class ImedicineTumor Cells CulturedAnimalsGlutathione PeroxidaseMice Inbred BALB CSuperoxide DismutaseMHC Class I GeneHistocompatibility Antigens Class INF-kappa BDeoxyguanosineGeneral Medicine3T3 CellsCatalaseFlow CytometryMolecular biologyGlutathioneOxidative Stressmedicine.anatomical_structureGene Expression Regulation8-Hydroxy-2'-Deoxyguanosinebiology.proteinCD8MethylcholanthreneFree radical research
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Differential modulation and prognostic values of immune-escape genes in uveal melanoma

2019

Uveal melanoma (UM) is the most common primary intraocular cancer in adults. In the present study, we aimed to characterize the immunological features of primary UM cancer and to provide an association with prognostic markers and outcome. Also, we assessed the influence of the microenvironment on the expression of inhibitory immune checkpoints in UM. Genes of interest included MHC Class I and Class II molecules, as well as inhibitory immune-checkpoints, i.e. PDL1, PDL2, B7-H3, B7-H4, TBFRSF6B, CD47, CD155, GAL9, HVEM and CD200. We observed significant lower levels of MHC genes in UM cells as compared to normal uveal melanocytes. Unexpectedly however, the expression levels of most of the ana…

Melanomas0301 basic medicineUveal NeoplasmsGenetics and Molecular Biology (all)Gene ExpressionUveal NeoplasmPathology and Laboratory MedicineBiochemistryEpitheliumMetastasisMajor Histocompatibility ComplexWhite Blood Cells0302 clinical medicineAnimal CellsBiochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)Medicine and Health SciencesImmune ResponseMelanomaMultidisciplinarybiologyT CellsMelanomaQRPrognosisGene typesOncology030220 oncology & carcinogenesisMedicineMelanocytesCellular TypesAnatomyResearch ArticleHumanPrognosiScienceImmune CellsImmunologyMHC class I genesMajor histocompatibility complex03 medical and health sciencesSigns and SymptomsImmune systemMelanocyteDiagnostic MedicineMHC class IGeneticsmedicineHumansChromatophoresInflammationBlood CellsCancers and NeoplasmsBiology and Life SciencesCancerBiochemistry; Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)Epithelial CellsCell BiologyBiomarkermedicine.diseaseBiological Tissue030104 developmental biologyAgricultural and Biological Sciences (all)Cancer cellbiology.proteinCancer researchClinical ImmunologyClinical MedicineBiomarkers
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2015

Small and isolated populations usually exhibit low levels of genetic variability, and thus, they are expected to have a lower capacity to adapt to changes in environmental conditions, such as exposure to pathogens and parasites. Comparing the genetic variability of selectively neutral versus functional loci allows one to assess the evolutionary history of populations and their future evolutionary potential. The genes of the major histocompatibility complex (MHC) control immune recognition of parasites, and their unusually high diversity is genes which is likely driven by parasite-mediated balancing selection. Here, we examined diversity and differentiation of neutral microsatellite loci and…

GeneticsGenetic diversityEcologyMHC Class I GeneZoologyBiologyMajor histocompatibility complexBalancing selectionGenetic structurebiology.proteinMicrosatelliteGenetic variabilityGeneEcology Evolution Behavior and SystematicsNature and Landscape ConservationEcology and Evolution
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